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This is the time it takes for your body to reduce the plasma levels by half. Prednisone is taken orally, but other systemic corticosteroids may be injected Get adequate rest (ideally seven to nine hours each night). Prednisone side effects may include: Increased sweating Trouble sleeping Weight gain and swelling Acne Nausea or heartburn Loss of appetite Skin thinning Bone loss (if used chronically) Who should not take prednisone?

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