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These studies showed that people taking Pristiq were also less likely to have their depression relapse (come back after improving) compared to those taking placebo. Public PostingsYou should be aware that if you voluntarily disclose information online in any community area, that information can be collected and used by others. This is a subjective assessment based on the strength of the available informations and our estimation of efficacy. SSRI vs SNRI Selective Serotonin Reuptake Inhibitors (SSRI) and Serotonin Norepinephrine Reuptake Inhibitors (SNRI) are two antidepressant drugs prescribed as a medication for depression.